反应详情

温度

40 °C

To a solution of 2-acetylcyclohexanone (25 g, 0.18 mol), potassium carbonate (29.5 g, 0.21 mol) and benzyltriethylammonium chloride (0.8 g, 0.0035 mol) in toluene (70 ml) was added ethyl acrylate (29 ml, 27 g, 0.27 mol) at room temperature. The mixture was heated at 40° C. for 20 hours, filtered and partitioned between distilled water (200 ml) and toluene (200 ml). The organic layer was dried over magnesium sulphate, filtered and concentrated under reduced pressure to give the title compound as a brown oil, (41.7 g, 97%) .

1. filtrationfiltered
2. custompartitioned
3. distillationbetween distilled water (200 ml) and toluene (200 ml)
4. dry with materialThe organic layer was dried over magnesium sulphate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure