Dimethylformamide dimethyl acetal → HCID 53733250, compound

HRID 374414Notes

Reaction equation

HRID 374414 reaction equation
[CH:1]1([C:4](=[O:16])[CH2:5][C:6]([C:8]2[C:13]([Cl:14])=[CH:12][C:11]([Cl:15])=[CH:10][N:9]=2)=[O:7])[CH2:3][CH2:2]1.CO[CH:19](OC)[N:20]([CH3:22])[CH3:21]>O1CCOCC1>[CH:1]1([C:4](=[O:16])[C:5](=[CH:19][N:20]([CH3:22])[CH3:21])[C:6]([C:8]2[C:13]([Cl:14])=[CH:12][C:11]([Cl:15])=[CH:10][N:9]=2)=[O:7])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 18996929HCID 18996929, compound

Product 1

HCID 53733250HCID 53733250, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 3-cyclopropyl-1-(3,5-dichloropyridin-2-yl)propan-1,3-dione (1.3 g) and N,N-dimethylformamide dimethyl acetal (1.1 ml) in 1,4-dioxane was stirred at room temperature for 4 days and the solvent was evaporated to yield 3-cyclopropyl-1-(3,5-dichloropyridin-2-yl)-2-dimethylaminomethylenepropan-1,3-dione (1.73 g).

Workup

  1. customthe solvent was evaporated

Sources & evidence

ORD record
ord-5c40c8bec8a94fbd9840686df03987dd
Source dataset
uspto-grants-1996_01
Patent number
US05480857

Reaction notes

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