Methanesulfonic Acid → HCID 178491136, compound

HRID 374434Notes

Reaction equation

HRID 374434 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH2:6]([NH:17][C:18]([NH2:20])=[NH:19])[C:7]1[CH:16]=[CH:15][C:12]([O:13][CH3:14])=[C:9]([O:10][CH3:11])[CH:8]=1>CO>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH2:6]([NH:17][C:18]([NH2:20])=[NH:19])[C:7]1[CH:16]=[CH:15][C:12]([O:13][CH3:14])=[C:9]([O:10][CH3:11])[CH:8]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 178491135HCID 178491135, compound

Product 1

HCID 178491136HCID 178491136, compoundYield 82.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanesulfonic acid (7.8 ml; 0.120 mol) is introduced into a suspension of veratrylguanidine (25 g; 0.119 mol) in 240 ml of methanol. The mixture is stirred at room temperature for one hour. The methanol is evaporated under vacuum, the oil obtained is precipitated by stirring for 15 min in tetrahydrofuran. The white solid is filtered, rinsed with tetrahydrofuran and ether and then dried under vacuum. 30 g of veratrylguanidine methanesulfonate are obtained with a yield of 82%.

Workup

  1. customThe methanol is evaporated under vacuum
  2. customthe oil obtained
  3. customis precipitated
  4. stirringby stirring for 15 min in tetrahydrofuran
  5. filtrationThe white solid is filtered
  6. washrinsed with tetrahydrofuran and ether
  7. customdried under vacuum

Sources & evidence

ORD record
ord-0ccdb4cfc4ad4613812f09ebafaa0421
Source dataset
uspto-grants-1996_01
Patent number
US05480884

Reaction notes

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