反应详情

A mixture of 2.00 g (7.5 moles) of 2-[3-(3-pyridinyl) propyl]-1H-isoindole-1,3 (2H) -dione, 8 mL of 2-propanol, and 1.71 g (10 mmoles) of benzyl bromide was heated under reflux for 1 hour. The solution was cooled to 0°, and the precipitated product was collected by suction filtration, washed with cold ethyl ether, and dried to afford 3.08 g of 3-[3-(2,3-dihydro-1,3-dioxo-1H-isoindol-2-yl)propyl]-1-(phenylmethyl)pyridinium bromide.

1. temperaturewas heated
2. temperatureunder reflux for 1 hour
3. temperatureThe solution was cooled to 0°
4. filtrationthe precipitated product was collected by suction filtration
5. washwashed with cold ethyl ether
6. customdried