Hydrochloric Acid → HCID 11405654, compound

HRID 374495Notes

Reaction equation

HRID 374495 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH:13]([CH2:15][O:16][C:17]3[CH:26]=[CH:25][C:20]([C:21]([O:23]C)=[O:22])=[CH:19][CH:18]=3)[O:12][C:11]2=[O:27])=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.CCOCC>C(O)(=O)C>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:14][CH:13]([CH2:15][O:16][C:17]3[CH:26]=[CH:25][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=3)[O:12][C:11]2=[O:27])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 15281822HCID 15281822, compound2×

Product 1

HCID 11405654HCID 11405654, compoundYield 85.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2.0 g of methyl 4-[3-(4-nitrophenyl)-2-oxooxazolidin-5-yl]methoxybenzoate (compound 50) obtained in Example 3 in 18 ml of acetic acid and 6 ml of concentrated hydrochloric acid was refluxed with heating for 12 hours. After ice-cooling the reaction solution, ether was added thereto and the crystals formed were collected by filtration. Thus, 1.64 g of the title compound (compound 81) was obtained (yield 85%).

Workup

  1. temperaturewith heating for 12 hours
  2. additionwas added
  3. customthe crystals formed
  4. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-f2df8096df16417891bb31bbdc40acbe
Source dataset
uspto-grants-1996_01
Patent number
US05480899

Reaction notes

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