Hydrochloric Acid → HCID 18997197, compound

HRID 374507Notes

Reaction equation

HRID 374507 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]([CH2:13][O:14][C:15]3[CH:24]=[CH:23][C:18]([C:19]([O:21]C)=[O:20])=[CH:17][CH:16]=3)[CH2:11][O:10][C:9]2=[O:25])=[CH:4][CH:3]=1.Cl>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]([CH2:13][O:14][C:15]3[CH:24]=[CH:23][C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=3)[CH2:11][O:10][C:9]2=[O:25])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18997214HCID 18997214, compound2×

Product 1

HCID 18997197HCID 18997197, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 1.30 g of methyl 4-[3-(4-chlorophenyl)-2-oxooxazolidin-4-yl]methoxybenzoate (compound 176) obtained in Example 22 in 18 ml of acetic acid and 10 ml of concentrated hydrochloric acid was refluxed with heating for 24 hours. The reaction mixture was concentrated under reduced pressure and the obtained residue was recrystallized from acetic acid-water to give 0.80 g of the title compound (compound 179) in a yield of 64%.

Workup

  1. temperaturewith heating for 24 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customthe obtained residue was recrystallized from acetic acid-water

Sources & evidence

ORD record
ord-acbf370c5f814797bbb916fa4426c719
Source dataset
uspto-grants-1996_01
Patent number
US05480899

Reaction notes

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