Toluene → HCID 15813877, compound

HRID 374565Notes

Reaction equation

HRID 374565 reaction equation
BrCCC[C:5]1[CH:15]=[CH:14][CH:13]=[C:7]2[C:8]([NH:10][C:11](=[O:12])[C:6]=12)=[O:9].[CH3:16][NH:17][CH2:18][C:19]#[CH:20].C(=O)([O-])[O-].[K+].[K+].[C:27]1(C)[CH:32]=CC=C[CH:28]=1>>[CH3:16][N:17]([CH2:32][C:27]#[CH:28])[CH2:18][CH2:19][CH2:20][N:10]1[C:11](=[O:12])[C:6]2[C:7](=[CH:13][CH:14]=[CH:15][CH:5]=2)[C:8]1=[O:9]

Participants

5

Reactant 4

HCID 1140TolueneHCID 11430Potassium CarbonateHCID 96160N-methylpropyn-2-ylamineHCID 21958088Bromopropylphthalimide

Product 1

HCID 15813877HCID 15813877, compound

Procedure

A mixture of bromopropylphthalimide (15.51 g, 0.058 mol), N-methyl-N-propargyl amine (5.0 g, 0.()72 mol), potassium carbonate (12.0 g, 0.087 mol), and toluene (40 ml) was refluxed for 4 hours, filtered and the insoluble washed with toluene. After removal of the solvent, the residue was dried in vacuo to provide 14.3 g of title product.

Workup

  1. temperaturewas refluxed for 4 hours
  2. filtrationfiltered
  3. washthe insoluble washed with toluene
  4. customAfter removal of the solvent
  5. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-62facbb4a3504fe28f0cbf79017b884e
Source dataset
uspto-grants-1996_01
Patent number
US05480988

Reaction notes

Loading…