Pyridine → HCID 178442495, compound

HRID 374594Notes

Reaction equation

HRID 374594 reaction equation
O=[C:2]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH2:3][C:4]([O:6]CC)=O.Cl.[NH2:16][OH:17].[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:23]([NH:18][C:4](=[C:3]1[C:4](=[O:6])[O:17][N:16]=[C:2]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH2:3][CH2:2][CH2:9][CH2:10][CH3:11])[CH2:22][CH2:21][CH2:20][CH3:19]

Participants

4

Reactant 3

HCID 1049PyridineHCID 245601Ethyl 3-oxononanoateHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 178442495HCID 178442495, compound

Procedure

3-n-Hexylisoxazol-5(4H)-one is obtained in 99% yield as a reddish liquid by holding ethyl 3-oxo-pelargonate at reflux temperature for 1 hour with one equivalent of hydroxylamine hydrochloride and one equivalent of pyridine and thereafter working-up in the usual manner.

Sources & evidence

ORD record
ord-833c89ff312e4ef4b0916e2c0fd87540
Source dataset
uspto-grants-1996_01
Patent number
US05481001

Reaction notes

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