Hydrogen Peroxide → 2,3-Dichloro-4-fluorobenzoic acid

HRID 374612Notes

Reaction equation

HRID 374612 reaction equation
[Cl:1][C:2]1[C:16]([Cl:17])=[C:15]([F:18])[CH:14]=[CH:13][C:3]=1[C:4](C1C=CC(F)=CC=1)=[O:5].[OH:19]O>>[F:18][C:15]1[CH:14]=[CH:13][C:3]([OH:19])=[CH:2][CH:16]=1.[Cl:1][C:2]1[C:16]([Cl:17])=[C:15]([F:18])[CH:14]=[CH:13][C:3]=1[C:4]([OH:5])=[O:19]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 189975842,3-Dichloro-4,4'-difluorobenzophenone

Product 2

HCID 97324-FluorophenolYield 60%HCID 103307052,3-Dichloro-4-fluorobenzoic acidYield 78%

Procedure

If the procedure is as described in Example 13, except that 50.1 g (0.175 mol) of 2,3-dichloro-4,4'-difluorobenzophenone and 10 g of 90 percent hydrogen peroxide, solution are used, 11.8 g (0.105 mol, 60%) of 4-fluorophenol and 28.3 g (0.136 mol, 78%) of 2,3-dichloro-4-fluorobenzoic acid are obtained.

Sources & evidence

ORD record
ord-96707dabb51a42a0bc4ab36dc61aea06
Source dataset
uspto-grants-1996_01
Patent number
US05481032

Reaction notes

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