Triethylamine → HCID 19935581, compound

HRID 37464Notes

Reaction equation

HRID 37464 reaction equation
[NH2:1][C:2]1[C:3]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[N:4][C:5](Cl)=[C:6]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].C(N(CC)CC)C>[Pd].C(OCC)(=O)C>[NH2:1][C:2]1[C:3]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[N:4][CH:5]=[C:6]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

5

Reactant 2

HCID 8471TriethylamineHCID 15289691HCID 15289691, compound

Product 1

HCID 19935581HCID 19935581, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 100 mg of 3-amino-6-chloro-4,5-diethoxycarbonyl-2-phenylpyridine, 0.08 ml (2.0 eq.) of triethylamine amd 8 ml of ethyl acetate was subjected to catalytic reduction for 7 hours with 100 mg of 10% Pd-C (50% wet). The catalyst was removed by filtration, and the solvent was distilled off. Yield: 86 mg(95.4%).

Workup

  1. customThe catalyst was removed by filtration
  2. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-18c0b61ab2be4aa6bd1effc977f42058
Source dataset
uspto-grants-1995_05
Patent number
US05420275

Reaction notes

Loading…