反应详情

温度

100 °C

To 0.8 g of 3-amino-4,5-dimethoxycarbonyl-6-methoxy-2-phenylpyridine was added 4 ml of hydrazine monohydrate. The mixture was heated at 100° C. in a stream of nitrogen for 1 hour. Under ice-cooling, water was added to the reaction mixture, followed by neutralization with hydrochloric acid for adjustment to pH 3. The resulting yellow crystalline precipitate was collected by filtration.

1. temperatureUnder ice-cooling
2. filtrationThe resulting yellow crystalline precipitate was collected by filtration