Citric Acid → HCID 67746012, compound

HRID 374828Notes

Reaction equation

HRID 374828 reaction equation
C([NH:4][C:5]1[CH:6]=[C:7](/[C:11](/[C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)=[CH:12]\[CH2:13][CH2:14][CH2:15][N:16]2[CH:20]=[N:19][N:18]=[N:17]2)[CH:8]=[CH:9][CH:10]=1)(=O)C.C(=O)(O)[O-].[Na+].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>Cl>[NH2:4][C:5]1[CH:6]=[C:7](/[C:11](/[C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)=[CH:12]\[CH2:13][CH2:14][CH2:15][N:16]2[CH:20]=[N:19][N:18]=[N:17]2)[CH:8]=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 311Citric AcidHCID 516892Sodium BicarbonateHCID 67745983HCID 67745983, compound

Product 1

HCID 67746012HCID 67746012, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

5.7 g of 4E-1-(5-(3-acetylaminophenyl)-5-(3-pyridyl)-pent-4-enyl)tetrazole are heated in 60 ml of 4N hydrochloric acid for 5 hours at 60° C. The reaction solution is neutralised by the addition of sodium bicarbonate and then adjusted to a pH value of 4-5 by the addition of citric acid. The aqueous phase is extracted with dichloromethane/methanol=4:1. The organic phase is washed with saturated sodium chloride solution, dried and concentrated by evaporation.

Workup

  1. extractionThe aqueous phase is extracted with dichloromethane/methanol=4:1
  2. washThe organic phase is washed with saturated sodium chloride solution
  3. customdried
  4. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-0daae5b465fa4e6ca3b7a4d82e1473aa
Source dataset
uspto-grants-1996_01
Patent number
US05482948

Reaction notes

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