Potassium Carbonate → HCID 18996341, compound

HRID 374896Notes

Reaction equation

HRID 374896 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[O:12][C:11](=[O:13])[N:10]([CH:14]([CH3:24])[CH2:15][C:16]3[CH:21]=[CH:20][C:19]([OH:22])=[C:18]([OH:23])[CH:17]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Br[C:26](Br)([C:30]([NH2:32])=[O:31])[C:27]([NH2:29])=[O:28].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[O:12][C:11](=[O:13])[N:10]([CH:14]([CH3:24])[CH2:15][C:16]3[CH:21]=[CH:20][C:19]4[O:22][C:26]([C:30]([NH2:32])=[O:31])([C:27]([NH2:29])=[O:28])[O:23][C:18]=4[CH:17]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 175375DibromomalonamideHCID 156692045-(3-Chlorophenyl)-3-(2-(3,4-dihydroxyphenyl)-1-methylethyl)-2-oxazolidinone

Product 1

HCID 18996341HCID 18996341, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

One equivalent of 5-(3-chlorophenyl) -3-(2-(3,4-dihydroxyphenyl)-1-methylethyl )-2-oxazolidinone, prepared by the procedure of U.S. Pat. No. 5,061,727; Example 1, one equivalent of dibromomalonamide, acetonitrile, and 4 equivalents of potassium carbonate are stirred at room temperature for 18 hours. The reaction mixture is filtered and evaporated in vacuo to give 5-(2-(5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-1,3 -benzodioxole-2,2-dicarboxamide.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customevaporated in vacuo

Sources & evidence

ORD record
ord-ec25c2c0d20840a7bbf12546cf75b605
Source dataset
uspto-grants-1996_01
Patent number
US05482971

Reaction notes

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