Hydroxyamine hydrochloride → HCID 18996272, compound

HRID 374925Notes

Reaction equation

[CH2:1]([C:3]1([CH2:24][CH3:25])[O:7][C:6]([C:9]2[CH:10]=[C:11]([S:14][C:15]3[CH:20]=[CH:19][C:18]([C:21](=O)[CH3:22])=[CH:17][CH:16]=3)[S:12][CH:13]=2)([CH3:8])[CH2:5][O:4]1)[CH3:2].Cl.[NH2:27][OH:28]>>[CH2:1]([C:3]1([CH2:24][CH3:25])[O:7][C:6]([C:9]2[CH:10]=[C:11]([S:14][C:15]3[CH:20]=[CH:19][C:18](/[C:21](=[N:27]/[OH:28])/[CH3:22])=[CH:17][CH:16]=3)[S:12][CH:13]=2)([CH3:8])[CH2:5][O:4]1)[CH3:2]

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 18996271HCID 18996271, compound

Product 1

HCID 18996272HCID 18996272, compoundYield 80%

Procedure

Using an analogous procedure to that described in Example 68, 4'-[4-(2,2-diethyl-4-methyl-1,3-dioxolan-4-yl)thien-2-ylthio]acetophenone was reacted with hydroxylamine hydrochloride to give (E)-4'-[4-(2,2-diethyl-4-methyl-1,3-dioxolan-4-yl)thien-2-ylthio]acetophenone oxime in 80% yield as a gum.

Sources & evidence

ORD record: ord-ff53eb5c8b394ac0b6e0cf6c9c306ef2
Source dataset: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05482966

Reaction notes

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