3,4-Dimethoxycarbonyl-2-methoxy-6-methyl-5-nitropyridine → HCID 15289707, compound

HRID 37513Notes

Reaction equation

HRID 37513 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6]([O:19][CH3:20])=[N:7][C:8]([CH3:18])=[C:9]([N+:15]([O-])=O)[C:10]=1[C:11]([O:13][CH3:14])=[O:12])=[O:4]>C(OCC)(=O)C.[Pd]>[NH2:15][C:9]1[C:8]([CH3:18])=[N:7][C:6]([O:19][CH3:20])=[C:5]([C:3]([O:2][CH3:1])=[O:4])[C:10]=1[C:11]([O:13][CH3:14])=[O:12]

Participants

4

Reactant 1

HCID 199355793,4-Dimethoxycarbonyl-2-methoxy-6-methyl-5-nitropyridine

Product 1

HCID 15289707HCID 15289707, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

In 5 ml of ethyl acetate was dissolved 350 mg of 3,4-dimethoxycarbonyl-2-methoxy-6-methyl-5-nitropyridine, and 300 mg of 10% Pd-C (50% wet) was added to the solution. Catalytic reduction reaction was conducted for 4.5 hours. After the reaction mixture was dried over magnesium sulfate, the solvent was distilled off to afford an oily product.

Workup

  1. additionwas added to the solution
  2. customCatalytic reduction reaction
  3. dry with materialAfter the reaction mixture was dried over magnesium sulfate
  4. distillationthe solvent was distilled off
  5. customto afford an oily product

Sources & evidence

ORD record
ord-c41010b4ebab483b8d14b7720d002562
Source dataset
uspto-grants-1995_05
Patent number
US05420275

Reaction notes

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