反应详情

A mixture of sodium hydride (0.5 g, 60%, 0.0125 mol) and tetrahydrofuran is treated with 2,3-dibromo-5-(p-chlorophenyl)-4-[(trifluoromethyl)sulfonyl]pyrrole (4.67 g, 0.01 mol), stirred for 15 minutes and treated with a solution of N-(hydroxymethyl)acetamide acetate (ester) (1.64 g, 0.0125 mol) in tetrahydrofuran. The reaction mixture is heated at reflux for 18 hours, concentrated in vacuo and poured into a water/ether mixture. The organic phase is separated, washed with water and brine, dried over anhydrous sodium sulfate and concentrated in vacuo to obtain the title product as a white solid (4.56 g).

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 18 hours
3. concentrationconcentrated in vacuo
4. additionpoured into a water/ether mixture
5. customThe organic phase is separated
6. washwashed with water and brine
7. dry with materialdried over anhydrous sodium sulfate
8. concentrationconcentrated in vacuo