反应详情

Mix 4,6-dibromoindole (2.09 g, 7.58 mmol), potassium carbonate (1.57 g, 11.4 mmol) and anhydrous methylene chloride (30 mL). Stir and add a solution of ethyl 3-bromo-2-hydroxyiminopropanoate (1.59 g, 7.58 mmol) in methylene chloride (20 mL). Stir under a nitrogen atmosphere for 48 hours. Take the solution up in ethyl acetate and wash with water (100 mL ), saturated sodium hydrogen carbonate (100 mL ) and brine (100 mL). Dry (MgSO4) and evaporate the solvent in vacuo and purify by silica gel chromatography to give the title compound.

1. stirringStir under a nitrogen atmosphere for 48 hours
2. washwash with water (100 mL ), saturated sodium hydrogen carbonate (100 mL ) and brine (100 mL)
3. dry with materialDry (MgSO4)
4. customevaporate the solvent in vacuo
5. custompurify by silica gel chromatography