Hydrochloric Acid → HCID 67742921, compound

HRID 375571Notes

Reaction equation

HRID 375571 reaction equation
O.[C:2]1([C:8]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)(O)[CH2:9][CH:10]2[CH2:15][CH2:14][CH2:13][N:12]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]4[O:24][CH2:25][O:26][C:20]=4[CH:19]=3)[CH2:11]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:34]>>[ClH:34].[C:28]1([C:8]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:9][CH:10]2[CH2:15][CH2:14][CH2:13][N:12]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]4[O:24][CH2:25][O:26][C:20]=4[CH:19]=3)[CH2:11]2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18993316HCID 18993316, compound

Product 1

HCID 67742921HCID 67742921, compoundYield 98%

Procedure

A solution of 3-(2,2-diphenyl-2-hydroxyethyl)-1-(3,4-methylenedioxyphenethyl)piperidine hydrate (162 mg) (Example 3) in 2M hydrochloric acid (4.5 ml) was heated at 100° C. for 30 minutes and evaporated to give the title compound as a colourless foam (165 mg, 98%), which was characterised as a hydrate.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-626b2b31ea914ddbb88278f8e27a28e4
Source dataset
uspto-grants-1996_01
Patent number
US05486527

Reaction notes

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