反应详情

Solid N-chlorosuccinimide (0.76 g 5.72 mmol) is added in portions over 5 minutes to a stirred solution of 3-[2(E)-(quinolin-2-yl)ethenyl]benzyl alcohol (1.14 g, 4.58 mmol) and triphenylphosphine (1.50 g, 5.72 mmol) in dichloromethane (100 ml) at 0°-5° C. The mixture is stirred for a further 2 hours at 0°-5° C. then evaporated and the residue chromatographed on silica in ethyl acetate-hexane (1:3).

1. customthen evaporated
2. customthe residue chromatographed on silica in ethyl acetate-hexane (1:3)