反应详情

A mixture of N-(1-phenylmethylpyrazol-5-yl) anthranilic acid (6 g) and POCl3 (60 ml) was heated on a steam bath overnight. The reaction mixture was poured into ice-water, neutralized with NH4OH and the precipitate which formed was collected by filtration, washed with water and dried to afford 5 g of 1-phenylmethyl-4-chloro-1H-pyrazolo[3,4-b]quinoline, as a light brown powder.

1. temperaturewas heated on a steam bath overnight
2. customthe precipitate which formed
3. filtrationwas collected by filtration
4. washwashed with water
5. customdried