反应详情

A mixture of N-(1-ethylpyrazole-5-yl)-5-acetamido anthranilic acid (2 g) and POCl3 (20 ml) was refluxed overnight. The reaction mixture was poured into ice-water (400 ml), neutralized with NH4OH and extracted with CH2Cl2 (3×100 ml). The CH2Cl2 layers were combined and concentrated in vacuo and the residue was purified by column chromatography on silica gel eluting with ethyl acetate to afford 0.2 g of 1-ethyl-4-chloro-6-acetamido-1H-pyrazolo[3,4-b]quinoline.

1. temperaturewas refluxed overnight
2. extractionextracted with CH2Cl2 (3×100 ml)
3. concentrationconcentrated in vacuo
4. customthe residue was purified by column chromatography on silica gel eluting with ethyl acetate