反应详情

A mixture of 2-chloro-5-(methylthio)benzoic acid (8.8 g, 0.043 mol), DMF (100 mL), 5-amino-1-ethylpyrazole (4.8 g, 0.043 mol), K2CO3 (5.94 g, 0.043 mol) and Cu(OAc)2 (0.5 g ) was refluxed overnight. The reaction mixture was cooled to room temperature, poured into water and acidified with acetic acid to a pH of about 4-5. The mixture was extracted with CH2Cl2 and then the CH2Cl2 layer was evaporated to afford 4.5 g of N-(1-ethylpyrazol-5-yl)-5-(methylthio)anthranilic acid.

1. temperaturewas refluxed overnight
2. extractionThe mixture was extracted with CH2Cl2
3. customthe CH2Cl2 layer was evaporated