2,2,2-Trifluoroethanol → HCID 21805461, compound

HRID 376025Notes

Reaction equation

HRID 376025 reaction equation
O.[OH-].[Li+].[CH2:4]([OH:9])[C:5]([F:8])([F:7])[F:6].[F:10][C:11]1[C:12](F)=[C:13]([F:23])[C:14]([F:22])=[C:15]2C(=O)[O:19][C:17](=[O:18])[C:16]=12>O>[F:6][C:5]([F:8])([F:7])[CH2:4][O:9][C:12]1[C:11]([F:10])=[C:16]([CH:15]=[C:14]([F:22])[C:13]=1[F:23])[C:17]([OH:19])=[O:18]

Participants

5

Reactant 3

HCID 64092,2,2-TrifluoroethanolHCID 69545Tetrafluorophthalic anhydride2×HCID 168937Lithium hydroxide, monohydrate

Product 1

HCID 21805461HCID 21805461, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

An initial charge comprising a mixture of 7.6 g of water, 2.1 g of lithium hydroxide hydrate, 10 g of trifluoroethanol and 2.2 g (10 mmol) of tetrafluorophthalic anhydride is heated at 70° C. for 96 hours, after which the content of tetrafluorophthalic anhydride has fallen to below 1% (GC). The procedure described in Example 3 is then followed to give 1.4 g (5.1 mmol, corresponding to 51%) of 3-trifluoroethoxy-2,4,5-trifluorobenzoic acid.

Workup

  1. additionAn initial charge

Sources & evidence

ORD record
ord-781e0eb28b764a7c901fa895c70e860e
Source dataset
uspto-grants-1996_01
Patent number
US05488152

Reaction notes

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