反应详情

45.0 g (0.25 mol) of 4-acetoxypentanoic acid chloride are dissolved in 450 ml of abs. tetrahydrofuran. Then 31.9 ml (0.27 mol) of 2,6-lutidine and 9 g of 5% Pd/C are added and hydrogenation is carried out for 1 hour at 10°-15° C. Upon cessation of hydrogenation, the catalyst and the 2,6-lutidine are removed by filtration and the filtrate is concentrated by evaporation. Distillation of the residue gives 4-acetoxypentanal as a colourless liquid of b.p.34 98°-100° C.

1. customUpon cessation of hydrogenation, the catalyst and the 2,6-lutidine are removed by filtration
2. concentrationthe filtrate is concentrated by evaporation
3. distillationDistillation of the residue