Hydrochloric Acid → HCID 19361678, compound

HRID 376257Notes

Reaction equation

HRID 376257 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:17]#N)=[C:7]2[C:11]=1[O:10][C:9]([CH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)=[CH:8]2.[OH-:19].[Na+].[OH:21]O.Cl>C(O)CCC>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:17]([OH:21])=[O:19])=[C:7]2[C:11]=1[O:10][C:9]([CH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)=[CH:8]2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 22009535HCID 22009535, compound

Product 1

HCID 19361678HCID 19361678, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

0.5 g of 7-methoxy-2-cyclopentylbenzofuran-4carbonitrile is heated to reflux for 5 h in a solution of 10 ml of n-butanol, 30 ml of sodium hydroxide solution (50% strength) and 2.5 ml of hydrogen peroxide (30% strength). The mixture is then diluted with ice water, acidified to pH 1-2 with 2 N hydrochloric acid and the precipitate formed is filtered off with suction, washed with water until acid-free and dried in vacuo: m.p. 170-171° C.

Workup

  1. customthe precipitate formed
  2. filtrationis filtered off with suction
  3. washwashed with water until acid-free and
  4. customdried in vacuo

Sources & evidence

ORD record
ord-3f42d42e08ee4d2d9ddf48916cbff71c
Source dataset
uspto-grants-2000_02
Patent number
US06020340

Reaction notes

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