Cysteamine → HCID 19361766, compound

HRID 376285Notes

Reaction equation

HRID 376285 reaction equation
CO[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[O:15][CH2:14][CH2:13][O:12]2)[N:6]=1)=[NH:4].N[CH2:17][CH2:18][SH:19]>C(Cl)(Cl)Cl>[S:19]1[CH2:18][CH2:17][N:4]=[C:3]1[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[O:12][CH2:13][CH2:14][O:15]2)[N:6]=1

Participants

4

Reactant 2

HCID 6058CysteamineHCID 53806627HCID 53806627, compound

Product 1

HCID 19361766HCID 19361766, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
130 °C

Procedure

1 g of 6-[1,3]dioxolan-2-yl-pyridine-2-carboximidic acid methyl ester (4.80 mmol) and 0.47 g of 2-aminoethanethiol (2.16 mmol) are mixed. The mixture is heated at 130° C. for 1 hour 30 minutes. The reaction mixture is taken up in chloroform, washed with water and then dried over magnesium sulfate. After filtration and evaporation of the solvent, the title product is isolated by chromatography on a silica column (eluent: chloroform/methanol; 98:2). 1.10 g of solid are recovered.

Workup

  1. washwashed with water
  2. dry with materialdried over magnesium sulfate
  3. filtrationAfter filtration and evaporation of the solvent

Sources & evidence

ORD record
ord-00887bf0f66241e4aaaad549b65fc379
Source dataset
uspto-grants-2000_02
Patent number
US06020345

Reaction notes

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