Ethanol → HCID 178513291, compound

HRID 376287Notes

Reaction equation

HRID 376287 reaction equation
O1CCOC1[C:6]1([C:12]#[N:13])[CH:11]=[CH:10][CH:9]=[CH:8][NH:7]1.Cl.[NH2:15][OH:16].[C:17](=[O:20])([O-])[O-:18].[K+].[K+].[CH2:23](O)[CH3:24]>>[O:18]1[CH2:24][CH2:23][O:20][CH:17]1[C:8]1[N:7]=[C:6]([C:12]([NH:15][OH:16])=[NH:13])[CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 4

HCID 702EthanolHCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 19361763HCID 19361763, compound

Product 1

HCID 178513291HCID 178513291, compound

Procedure

0.88 g of 2-[1,3]dioxolan-2-yl-pyridine-2-carbonitrile (4.99 mmol), 1.74 g of hydroxylamine hydrochloride (25 mmol) and 3.45 g of potassium carbonate (25 mmol) are mixed in 15 ml of ethanol and then the reaction mixture is heated under reflux for 4 hours. After evaporation of the ethanol, the title product is crystallized by addition of water to the residue. 0.80 g of a colorless powder is recovered.

Workup

  1. temperaturethe reaction mixture is heated
  2. temperatureunder reflux for 4 hours
  3. customAfter evaporation of the ethanol
  4. customthe title product is crystallized by addition of water to the residue
  5. custom0.80 g of a colorless powder is recovered

Sources & evidence

ORD record
ord-16f171cee7334d3fba33f76675b2464e
Source dataset
uspto-grants-2000_02
Patent number
US06020345

Reaction notes

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