反应详情

A mixture of 3.10 g of 6-[1,3]dioxolan-2-yl-pyridine-2-carbaldehyde (17.3 mmol), 9.26 g of (methyl)triphenylphosphonium bromide (25.9 mmol) and 4.80 g of potassium carbonate (34.8 mmol) in 60 ml of 1,4-dioxane is maintained under reflux for 5 hours. The solid is removed by filtration and then the solvent is evaporated off. The residue is taken up in ethyl acetate, the solution is washed with water and then with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate and filtered. After evaporation of the solvent, the title compound is isolated by chromatography on a silica column (eluent: hexane/ethyl acetate; 80:20). 1.63 g of a yellow oil are obtained.

1. temperatureis maintained
2. temperatureunder reflux for 5 hours
3. customThe solid is removed by filtration
4. customthe solvent is evaporated off
5. washthe solution is washed with water
6. dry with materialwith a saturated aqueous solution of sodium chloride, dried over magnesium sulfate
7. filtrationfiltered
8. customAfter evaporation of the solvent