Tetrahydrofuran → HCID 53783123, compound

HRID 376408Notes

Reaction equation

HRID 376408 reaction equation
[CH3:1][O:2][C:3](=[O:30])[C@@H:4]([NH:21]C(=O)C1C=CC=CC=1)[CH2:5][C:6]([C:8]1[CH:20]=[CH:19][C:11]2[O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:10]=2[CH:9]=1)=[O:7].O1CCCC1>C(N(CC)CC)C>[NH2:21][C@@H:4]([CH2:5][C:6]([C:8]1[CH:20]=[CH:19][C:11]2[O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:10]=2[CH:9]=1)=[O:7])[C:3]([O:2][CH3:1])=[O:30]

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 53903994HCID 53903994, compound

Product 1

HCID 53783123HCID 53783123, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

(S)-2-Benzoylamino-4-dibenzofuran-2-yl-4-oxo-butyric acid methyl ester, prepared as described in Step (b) of Example 6, was dissolved in tetrahydrofuran containing one equivalent of triethylamine. The solution was stirred at room temperature for 1 hour, and then the solvent was removed by evaporation to give a solid. The solid was washed with water to give methyl (S)-2-amino-4-dibenzofuran-2-yl-4-oxo-butyrate as a mono-hydrate.

Workup

  1. customthe solvent was removed by evaporation
  2. customto give a solid
  3. washThe solid was washed with water

Sources & evidence

ORD record
ord-371b9156d7394c8f966e88374e4890fd
Source dataset
uspto-grants-2000_02
Patent number
US06020366

Reaction notes

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