Pyridine → HCID 19361955, compound

HRID 376449Notes

Reaction equation

HRID 376449 reaction equation
[F:1][C:2]1[CH:8]=[C:6](N)[C:5]([CH3:9])=[CH:4][CH:3]=1.N(OCCCCC)=O.[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:9])=[C:6]([C:21]2[CH:22]=[CH:23][N:18]=[CH:19][CH:20]=2)[CH:8]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 10026Pentyl nitriteHCID 677745-Fluoro-o-toluidine

Product 1

HCID 19361955HCID 19361955, compound

Procedure

5-Fluorotoluidine (Example1,B), pyridine and pentyl nitrite are warmed until a vigorous reaction with evolution of gas sets in. This is allowed to proceed without heating until it has subsided (20 minutes) and the mixture is boiled under reflux for another 100 minutes. The excess pyridine is removed under reduced pressure to yield the title product.

Workup

  1. temperaturewithout heating until it
  2. custom(20 minutes)
  3. temperatureunder reflux for another 100 minutes
  4. customThe excess pyridine is removed under reduced pressure

Sources & evidence

ORD record
ord-41e13e5998024234b116bfe9284b909b
Source dataset
uspto-grants-2000_02
Patent number
US06020379

Reaction notes

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