Triethylamine → HCID 178513436, compound

HRID 376544Notes

Reaction equation

HRID 376544 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]#[N:12])=[CH:6][CH:5]=1)([OH:3])=[O:2].Cl.[NH2:14][OH:15].C(N(CC)CC)C>CO>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11]([NH:14][OH:15])=[NH:12])=[CH:8][CH:9]=1)([OH:3])=[O:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 129823264-CYANAMINOBENZOIC ACID

Product 1

HCID 178513436HCID 178513436, compoundYield 56.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 150 ml of methanol was dissolved 6.56 g of 4-carboxyphenyl cyanamide produced in Reference Example 26. To the solution were added, while stirring at room temperature, 6.1 g of hydroxylamine hydrochloride and 8.88 g of triethylamine. The mixture was stirred for two hours. The resulting crystalline precipitate was collected by filtration to afford 4.45 g of the title compound as a colorless crystalline product.

Workup

  1. customproduced in Reference Example 26
  2. additionTo the solution were added
  3. stirringThe mixture was stirred for two hours
  4. filtrationThe resulting crystalline precipitate was collected by filtration

Sources & evidence

ORD record
ord-b7740643974b46bda716419a9cfdd8d2
Source dataset
uspto-grants-2000_02
Patent number
US06020334

Reaction notes

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