Hydroxylamine → 4-t-Butoxycarbonyl benzaldoxime

HRID 376546Notes

Reaction equation

HRID 376546 reaction equation
[C:1]([O:5][C:6](=[O:15])[C:7]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[CH:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2].N[OH:17].C(N(CC)CC)C>CO>[C:1]([O:5][C:6]([C:7]1[CH:8]=[CH:9][C:10]([CH:13]=[N:14][OH:17])=[CH:11][CH:12]=1)=[O:15])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 787HydroxylamineHCID 8471TriethylamineHCID 271408Tert-butyl 4-cyanobenzoate

Product 1

HCID 867537874-t-Butoxycarbonyl benzaldoximeYield 51.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 100 ml of methanol were dissolved 20.5 g of 4-cyanobenzoic acid t-butyl ester and 13.9 g of hydroxylamine. To the solution was added, while stirring at room temperature, 128 g of triethylamine, and the mixture was stirred for one hour at 85° C. The reaction mixture was concentrated under reduced pressure. The concentrate was dissolved in ethyl acetate, and the solution was washed with water. The organic layer was concentrated under reduced pressure to give a crude product, which was recrystallized from isopropyl ether to afford 11.45 g of the title compound as a colorless crystalline product.

Workup

  1. additionTo the solution was added
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. dissolutionThe concentrate was dissolved in ethyl acetate
  4. washthe solution was washed with water
  5. concentrationThe organic layer was concentrated under reduced pressure
  6. customto give a crude product, which
  7. customwas recrystallized from isopropyl ether

Sources & evidence

ORD record
ord-04dbb81ec03d48a5af32ad171d108224
Source dataset
uspto-grants-2000_02
Patent number
US06020334

Reaction notes

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