HCID 17869403, compound → HCID 19359092, compound

HRID 376765Notes

Reaction equation

HRID 376765 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[N:17][C:18]([C:21]3[CH:22]=[N:23][C:24]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])=[CH:25][CH:26]=3)=[N:19][CH:20]=2)=[C:11]([F:40])[C:10]=1[F:41])C1C=CC=CC=1>C1COCC1>[F:40][C:11]1[C:10]([F:41])=[C:9]([OH:8])[CH:14]=[CH:13][C:12]=1[C:15]1[CH:20]=[N:19][C:18]([C:21]2[CH:22]=[N:23][C:24]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])=[CH:25][CH:26]=2)=[N:17][CH:16]=1

Participants

3

Reactant 1

HCID 17869403HCID 17869403, compound

Product 1

HCID 19359092HCID 19359092, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The hydrogenation of 2.5 mmol of 5-(4-benzyloxy-2,3-difluorophenyl)-2-(6-dodecyloxypyridin-3-yl)pyrimidine in 50 ml of THF is carried out analogously to the procedure indicated for precursor 14, giving 0.7 g (60%) of a colorless solid, m.p. 111-118° C.

Sources & evidence

ORD record
ord-e3dc538d8da345a7bcf87edad2e7ac79
Source dataset
uspto-grants-2000_02
Patent number
US06022492

Reaction notes

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