反应详情

A mixture of 2-methyl-5-hydroxy-1H-indene-3-acetic acid methyl ester (1.8 g, 8.25 mmol), powdered anhydrous potassium carbonate (1.13 g, 8.25 mmol) and 18-crown-6 (0.219 g) in acetonitrile (21 mL) is stirred at room temperature for 15 minutes. 2-(Chloromethyl)quinoline (1.6 g, 9.08 mmol) is then added and the mixture is stirred for 15 hours at 65° C. After the solvent is removed, the residue is partitioned between water and ethyl acetate. The organic phase is dried over MgSO4 and evaporated. The crude product is purified by flash chromatography (eluant: methylene chloride-ethyl acetate) to afford 2.35 g (79%) of the desired product.

1. stirringthe mixture is stirred for 15 hours at 65° C
2. customAfter the solvent is removed
3. customthe residue is partitioned between water and ethyl acetate
4. dry with materialThe organic phase is dried over MgSO4
5. customevaporated
6. customThe crude product is purified by flash chromatography (eluant: methylene chloride-ethyl acetate)