反应详情

A suspension of 2-[6-[(3-hydroxyphenyl)methyl]-1-cyclohexen-1-yl]-4,5-diphenyloxazole (885 mg), ethyl bromoacetate (399 mg), and potassium carbonate (360 mg) in N,N-dimethylformamide was stirred at room temperature for 3 days and partitioned between ethyl acetate and water. The organic layer was separated, washed with water (twice) and brine, dried over magnesium sulfate, and evaporated in vacuo. The oily residue was purified by column chromatography on silica gel (n-hexane--ethyl acetate (20:1)) to afford ethyl [3-[[2-(4,5-diphenyl-2-oxazolyl)-2-cyclohexen-1-yl]methyl]phenoxy]acetate (847 mg) as a solid.

1. custompartitioned between ethyl acetate and water
2. customThe organic layer was separated
3. washwashed with water (twice) and brine
4. dry with materialdried over magnesium sulfate
5. customevaporated in vacuo
6. customThe oily residue was purified by column chromatography on silica gel (n-hexane--ethyl acetate (20:1))