HCID 53831028, compound → HCID 53769712, compound

HRID 377336Notes

Reaction equation

HRID 377336 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([CH:18]=[C:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH:20]3[C:25]3[CH:26]=[C:27]([CH:35]=[CH:36][CH:37]=3)[O:28][CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.O1CCCC1.[Pd]>[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH:20]3[C:25]3[CH:26]=[C:27]([CH:35]=[CH:36][CH:37]=3)[O:28][CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])[O:10][C:11]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 1

HCID 53831028HCID 53831028, compound

Product 1

HCID 53769712HCID 53769712, compoundYield 69.7%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of ethyl [3-[2-[(4,5-diphenyloxazol-2-yl)methylene]cyclohexan-1-yl]phenoxy]acetate (300 mg) in a mixture of ethanol (10 ml) and tetrahydrofuran (10 ml) was added 10% palladium on carbon (50 mg). After being stirred for 4 hours under hydrogen atmosphere, the reaction mixture was filtered. The solvent was evaporated in vacuo to give ethyl [3-[2-[(4,5-diphenyloxazol-2-yl)methyl]cyclohexan-1-yl]phenoxy]acetate (210 mg).

Workup

  1. filtrationthe reaction mixture was filtered
  2. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-c229a6887ec34237a8bfade9987babf6
Source dataset
uspto-grants-2000_02
Patent number
US06025375

Reaction notes

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