反应详情

Potassium hydroxide (1.47 g), tetrabutyl ammonium chloride (0.77 g) and H2O (1 ml) are added to a solution of the product obtained in Step 6. (6.6 g) in 1,3-dibromopropane (27 ml). The reaction mixture is stirred for 20 hours and diluted with diethyl ether and washed with 5% aq. HCl. The acidic solution is washed with ether and basified, affording an oil which is taken up in ether, washed with sat'd NaCl, dried, filtered and evaporated in vacuo affording the desired product as an oil.

1. washwashed with 5% aq. HCl
2. washThe acidic solution is washed with ether
3. custombasified, affording an oil which
4. washwashed with sat'd NaCl
5. customdried
6. filtrationfiltered
7. customevaporated in vacuo