N-Methylbenzylamine → HCID 19358862, compound

HRID 377511Notes

Reaction equation

Cl[C:2]1[C:7]([N+:8]([O-])=O)=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[CH3:12][NH:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH2:21]([C:23]1[NH:24][CH:25]=[CH:26][N:27]=1)[CH3:22].[Sn](Cl)Cl.[C:31](N1C=CN=C1)(N1C=CN=C1)=[O:32]>>[CH2:21]([C:23]1[N:27]2[C:26]([C:31](=[O:32])[NH:8][C:7]3[C:2]([N:13]([CH2:14][C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH3:12])=[N:3][CH:4]=[N:5][C:6]=32)=[CH:25][N:24]=1)[CH3:22]

Participants

Reactant 5

HCID 7669N-Methylbenzylamine

HCID 203124,6-Dichloro-5-nitropyrimidine

HCID 24479Stannous Chloride

HCID 661302-Ethylimidazole

HCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 19358862HCID 19358862, compound

Procedure

Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with N-methyl benzylamine, reaction with 2-ethylimidazole, reduction with tin (II) chloride and cyclization with carbonyldiimidazole.

Sources & evidence

ORD record: ord-f3458a4ceac644c19c71b2798b5065d6
Source dataset: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06025489

Reaction notes

Loading…