Hydrochloric Acid → HCID 19358849, compound

HRID 377513Notes

Reaction equation

HRID 377513 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-])=O)=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[CH3:12][N:13]1[CH2:18][CH2:17][CH:16]([NH:19]CC2C=CC=CC=2)[CH2:15][CH2:14]1.[CH2:27]([C:29]1[NH:30][CH:31]=[CH:32][N:33]=1)[CH3:28].[Sn](Cl)Cl.[C:37](N1C=CN=C1)(N1C=CN=C1)=[O:38].Cl>>[CH2:27]([C:29]1[N:33]2[C:32]([C:37](=[O:38])[NH:8][C:7]3[C:2]([NH:19][CH:16]4[CH2:15][CH2:14][N:13]([CH3:12])[CH2:18][CH2:17]4)=[N:3][CH:4]=[N:5][C:6]=32)=[CH:31][N:30]=1)[CH3:28]

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 203124,6-Dichloro-5-nitropyrimidineHCID 24479Stannous ChlorideHCID 661302-EthylimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 1114650BENZYL-(1-METHYL-PIPERIDIN-4-YL)-AMINE

Product 1

HCID 19358849HCID 19358849, compound

Procedure

Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with 1-methyl-4-(benzylamino)piperidine, followed by reaction with 2-ethylimidazole, reduction with tin (II) chloride, cyclization with carbonyldiimidazole and debenzylation with refluxing 6 N HCl for 30 minutes.

Sources & evidence

ORD record
ord-6d752d0d2bb845a9ba4c3b2c55d9f26f
Source dataset
uspto-grants-2000_02
Patent number
US06025489

Reaction notes

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