反应详情

To a stirred solution of 4-acetyl-5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethoxyphenyl)pyrazole (0.302 g) in tetrahydrofuran (10 ml) at 2° C. was added t-butylnitrite (0.66 ml). The mixture was heated under reflux for 1.5 hours and then evaporated. The residue was purified by column chromatography on silica gel eluted with dichloromethane. Combination and evaporation of suitable fractions provided the title compound as a white solid, m.p. 105.7-106.6° C.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 1.5 hours
3. customevaporated
4. customThe residue was purified by column chromatography on silica gel
5. washeluted with dichloromethane
6. customCombination and evaporation of suitable fractions