Oxalyl chloride → HCID 86755159, compound

HRID 377753Notes

Reaction equation

HRID 377753 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)/[C:8](=[CH:12]\[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)/[C:7]([CH3:19])=[C:6]2[CH2:20][C:21]([OH:23])=O.C(Cl)(=O)C([Cl:27])=O>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)/[C:8](=[CH:12]\[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)/[C:7]([CH3:19])=[C:6]2[CH2:20][C:21]([Cl:27])=[O:23]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 10542687HCID 10542687, compound

Product 1

HCID 86755159HCID 86755159, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(Z)-5-methoxy-2-methyl-1-benzylidene-3-indenylacetic acid (70 mmol) in THF (500 ml) is allowed to react with oxalylchloride (2 M in CH2Cl2 ; 70 mmol) under reflux conditions (24 hours). The solvent is evaporated to yield the title compound, which is used as such in the next step.

Workup

  1. customThe solvent is evaporated

Sources & evidence

ORD record
ord-b3435f67861b4e78b2b87380281aeea1
Source dataset
uspto-grants-2000_02
Patent number
US06028116

Reaction notes

Loading…