Oxalyl chloride → HCID 86755160, compound

HRID 377754Notes

Reaction equation

HRID 377754 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]([CH3:24])[C:7]([Cl:23])([CH:22]=1)/[CH:8]=[C:9](/[C:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH:14]=1)\[C:10](O)=[O:11].C(Cl)(=O)C([Cl:28])=O>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]([CH3:24])[C:7]([Cl:23])([CH:22]=1)/[CH:8]=[C:9](/[C:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH:14]=1)\[C:10]([Cl:28])=[O:11]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 86755161HCID 86755161, compound

Product 1

HCID 86755160HCID 86755160, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(Z)-5-Methoxy-2-methyl-1-chlorobenzylidene-3-indenylacetic acid (70 mmol) in THF (500 ml) is allowed to react with oxalylchloride (2 M in CH2Cl2 ; 70 mmol) under reflux conditions (24 hours). The solvent is evaporated to yield the title compound, which is used as such in the next step.

Workup

  1. customThe solvent is evaporated

Sources & evidence

ORD record
ord-c28abf2d85e14010b760a69bd96b959f
Source dataset
uspto-grants-2000_02
Patent number
US06028116

Reaction notes

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