Oxalyl chloride → HCID 86755165, compound

HRID 377764Notes

Reaction equation

HRID 377764 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH2:23][C:24](O)=[O:25])=[C:7]([CH3:22])/[C:8]/2=[CH:11]/[C:12]2[CH:17]=[CH:16][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:14][CH:13]=2)=[CH:4][C:3]=1[O:27][CH3:28].C(Cl)(=O)C([Cl:32])=O>C1COCC1>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH2:23][C:24]([Cl:32])=[O:25])=[C:7]([CH3:22])/[C:8]/2=[CH:11]/[C:12]2[CH:17]=[CH:16][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:14][CH:13]=2)=[CH:4][C:3]=1[O:27][CH3:28]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 70288037HCID 70288037, compound

Product 1

HCID 86755165HCID 86755165, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(Z)-6-fluoro-5-methoxy-2-methyl-1-(p-methylsulfonylbenzylidene)-3-indenylacetic acid (70 mmol) in THF (500 ml) is allowed to react with oxalylchloride (2 M in CH2Cl2 ; 70 mmol) under reflux conditions (24 hours). The solvent is evaporated to yield the title compound, which is used as such in the next step.

Workup

  1. customThe solvent is evaporated

Sources & evidence

ORD record
ord-27f630133feb4b3ab59464e929286a51
Source dataset
uspto-grants-2000_02
Patent number
US06028116

Reaction notes

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