反应详情

0.76 g of 4-phenoxy phenol was dissolved in 10 ml of acetone followed by adding 0.6 g of anhydrous potassium carbonate and 1.0 g of 2-bromomethyl-5-ethoxy-1,3,4-thiadiazole. The resulting mixture was refluxed with stirring and heated for 2 hours. After cooling, 100 ml of ethyl acetate was added followed by washing with water for two times, and the resulting ethyl acetate layer was dried over anhydrous magnesium sulfate. Ethyl acetate was distilled over under reduced pressure, and the residue was purified by chromatography on silica gel to obtain 1.0 g of the compound No. 1 described in Table 1.

1. temperatureThe resulting mixture was refluxed
2. temperatureheated for 2 hours
3. temperatureAfter cooling
4. washby washing with water for two times
5. dry with materialthe resulting ethyl acetate layer was dried over anhydrous magnesium sulfate
6. distillationEthyl acetate was distilled over under reduced pressure
7. customthe residue was purified by chromatography on silica gel