反应详情

The crude 4-isopropylphenylacetylene was dissolved in triethylamine (100 mL). 4-iodoisopropylbenzene (12.3 g, 50 mmol), dichlorobis(triphenylphosphine)palladium(II) (0.70 g, 1 mmol), and copper(I) iodide (1.5 g) were added. The reaction was stirred at room temperature for 2 days, heated to reflux for 1 hour, cooled, diluted with hexanes, and filtered. The filtrate was evaporated under reduced pressure. The residue was filtered through a pad of silica gel with hexanes, and the solvent was evaporated to give 11.40 g (87%) of 1,2-bis(4-(2-propyl)phenyl)acetylene.

1. temperatureheated
2. temperatureto reflux for 1 hour
3. temperaturecooled
4. filtrationfiltered
5. customThe filtrate was evaporated under reduced pressure
6. filtrationThe residue was filtered through a pad of silica gel with hexanes
7. customthe solvent was evaporated