HCID 19353305, compound → HCID 19353328, compound

HRID 378255Notes

Reaction equation

HRID 378255 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:11]4[CH2:12][N:13]([C:27]([CH2:29][CH2:30][C:31]([O:33]CC5C=CC=CC=5)=[O:32])=[O:28])[C:14](=[O:26])[C:15]=4[CH:16]=[C:17]4[CH:25]=[CH:24][C:23]5[O:22][CH2:21][O:20][C:19]=5[C:18]=34)=[CH:9][C:4]=2[O:3][CH2:2]1>[C].[Pd].C(OCC)(=O)C>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:11]4[CH2:12][N:13]([C:27]([CH2:29][CH2:30][C:31]([OH:33])=[O:32])=[O:28])[C:14](=[O:26])[C:15]=4[CH:16]=[C:17]4[CH:25]=[CH:24][C:23]5[O:22][CH2:21][O:20][C:19]=5[C:18]=34)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

4

Reactant 1

HCID 19353305HCID 19353305, compound

Product 1

HCID 19353328HCID 19353328, compoundYield 67.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To an ethyl acetate (2 ml) solution of Benzyl 3-[10-(1,3-benzodioxol-5-yl)-8,9-dihydro-7H-1,3-benzodioxolo[4,5-f]isoindol-7-one-8-yl]carbonyl-propionate (50 mg) was added 10% palladium carbon (10 mg) and stirred overnight under hydrogen atmosphere. The catalysts were filtered off and the filtrate was concentrated under reduced pressure, then recrystallized from ethyl acetate-hexane to give the entitled compound (28 mg) as colorless crystals.

Workup

  1. filtrationThe catalysts were filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customrecrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-17d84f42ea3a415bab0800030ecbc4e1
Source dataset
uspto-grants-2000_02
Patent number
US06030967

Reaction notes

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