Hydrochloric Acid → HCID 22476022, compound

HRID 378323Notes

Reaction equation

HRID 378323 reaction equation
C1(=O)N[C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.NN.Cl.N[CH2:16][C:17]1[CH:18]=[N:19]C(C#N)=N[CH:22]=1.Cl>>[NH2:19][CH2:18][C:17]1[CH:16]=[CH:22][C:17]([C:18]#[N:19])=[CH:16][C:22]=1[O:6][CH2:4][C:3]1[CH:2]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 6809PhthalimideHCID 9321HydrazineHCID 22476050182287-56-5

Product 1

HCID 22476022HCID 22476022, compound

Procedure

Synthesis took place via the stage of the corresponding phthalimide as in Example 3.(f). The hydrazine cleavage was carried out as in Example 3.(g). The free amine was generated at pH 9-10 from the initially produced hydrochloride and was extracted from the aqueous solution with ether. 1H-NMR (DMSO-d6, δ in ppm): 7.65-7.25 (8H), 5.20 (s, 2H), 3.80 (s, 2H), ca. 3.0 (broad signal, NH2)

Workup

  1. customSynthesis
  2. extractionwas extracted from the aqueous solution with ether

Sources & evidence

ORD record
ord-5ee5a461058244ecbaab1baf4939c131
Source dataset
uspto-grants-2000_02
Patent number
US06030972

Reaction notes

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