反应详情

温度

60 °C

13.8 g (0.1 mmol) of 1,2,3,4-tetrahydroquinoline was dissolved in 60 ml of N,N-dimethylformamide, followed by the addition of 21.1 g (0.124 mmol) of isopropyl iodide and 20.6 g (0.208 mol) of potassium carbonate. The obtained mixture was stirred under heating at 60° C. for 5 hours. Water was added to the resulting reaction mixture, followed by the extraction with ethyl acetate. The organic phase was washed with a saturated aqueous solution of common salt, dried over anhydrous magnesium sulfate, and concentrated in a vacuum. The obtained residue was purified by silica gel column chromatography (3% ethyl acetate/n-hexane) to give 13.1 g of the title compound as a colorless oil.

1. extractionfollowed by the extraction with ethyl acetate
2. washThe organic phase was washed with a saturated aqueous solution of common salt
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated in a vacuum
5. customThe obtained residue was purified by silica gel column chromatography (3% ethyl acetate/n-hexane)