反应详情

To a solution of (Z)-2-(2-aminothiazol-4-yl)-2-(triphenylmethoxyimino)ace tic acid (5.81 g, 13.47 mmol) in DMF (30 mL) at room temperature (1 mL) was added N-chlorosuccinimide (1.80 g, 13.47 mmol). After overnight reaction the reaction mixture was poured into water (about 500 mL) and the resulting precipitate was filtered, washed with water and then with ethyl acetate and dried in vacuum to afford 4.43 g (71%) of the title compound. 13C NMR (CDCl3) δ108.5 , 125.6 ,126.2 , 126.6 , 12.3 , 134.7 141.8, 146.5 , 162.1 , 163.3.

1. customAfter overnight reaction the reaction mixture
2. filtrationthe resulting precipitate was filtered
3. washwashed with water
4. dry with materialwith ethyl acetate and dried in vacuum