Triethylamine → HCID 18349749, compound

HRID 378618Notes

Reaction equation

HRID 378618 reaction equation
[CH2:1]([S:5](Cl)(=[O:7])=[O:6])[CH2:2][CH2:3][CH3:4].[N:9]1([CH2:14][CH2:15][CH2:16][NH:17][C:18]([C:21]2[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][CH:22]=2)([CH3:20])[CH3:19])[CH:13]=[CH:12][N:11]=[CH:10]1.C(N(CC)CC)C>ClCCl>[CH2:1]([S:5]([O:27][C:24]1[CH:25]=[CH:26][C:21]([C:18]([NH:17][CH2:16][CH2:15][CH2:14][N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)([CH3:20])[CH3:19])=[CH:22][CH:23]=1)(=[O:7])=[O:6])[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 754301-Butanesulfonyl chlorideHCID 18349573HCID 18349573, compound

Product 1

HCID 18349749HCID 18349749, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a similar manner to Example 71, a solution of butanesulphonyl chloride (0.45 g) in dichloromethane (5 ml) was added in portions over 5 minutes to a solution of 4-{1-[3-(imidazol-1-yl)propylamino]-1-methylethyl}phenol (0.75 g) and triethylamine (0.29 g) in dicloloromethane (5 ml) at 0° C. with stirring, to give 4-{1-[3-(imidazol-1-yl)propylamino]-1-methylethyl}phenyl 1-butanesulphonate as an oil.

Sources & evidence

ORD record
ord-81d106117fc64d1a85570652902686ec
Source dataset
uspto-grants-2000_02
Patent number
US06031109

Reaction notes

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